For an oocyte to generally be All set for fertilization and growth into an embryo, the ideal list of genes has to be turned on. Namekawa suspected this pre-programming of your oocyte genome occurs in numerous stages — the very first just one commencing across the time a female is born. He believed that chromatin remodeling proteins did Significantly of the do the job, by shifting spools about.
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“If we know the way this chromatin condition is set up, and how it relates to oocyte good quality, it could at some point result in therapies for a few sorts of infertility,” suggests Namekawa.
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This could assistance clarify why older women usually tend to bear children with chromosomal Issues like Down Syndrome, wherein an additional copy of chromosome 21 finds its way into an oocyte — and afterwards, an embryo.
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